药物使用障碍:呼吁一个阶段化范式
Keren Bachi1,2,3, Yasmin L Hurd1,2,4,5, Edwin A Salsitz6,7
1Addiction Institute of Mount Sinai, New York, NY, USA.
Translational psychiatry
|August 1, 2025
概括
药物使用障碍 (SUD) 与其他慢性疾病一样缺乏临床阶段. 结合社会因素的新动态模型可以个性化SUD治疗并推进成研究.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 临床医学 临床医学
背景情况:
- 药物使用障碍 (SUDs) 越来越多地被认为是慢性脑部疾病.
- 目前的表征缺乏与其他慢性疾病相比的明显的临床阶段.
- 这种差距阻碍了个性化治疗策略和研究结果的临床应用.
研究的目的:
- 为SUDs提出一个动态的,结构化的分阶段模型.
- 整合多维因素,包括健康的社会决定因素 (SDOH),进入SUD分类.
- 加强个性化治疗方法,促进成研究的临床转化.
主要方法:
- 为一个动态的SUD分期模型开发概念框架.
- 包括各种因素,如神经生物学,心理和健康的社会决定因素.
- 文献综述和现有慢性疾病病期模型的综合.
主要成果:
- 为SUDs提出了一个多维的,动态的分期模型.
- 确定确定阶段的关键因素,包括SDOH的严重程度,慢性和影响.
- 改善患者分层和量身定制干预的潜力.
结论:
- 动态分期模型对于推进SUD临床管理至关重要.
- 将SDOH整合到分期可以带来更公平,更有效的护理.
- 这一框架为增强个性化成医学和研究翻译提供了一条途径.
相关概念视频
Substance Use Disorders Affecting Sleep
217
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
217
Drug Abuse and Addiction: Pharmacological Phenomena
656
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
656
Drug Dependence
1.2K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.2K
Psychosis: Goals of Pharmacotherapy
209
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
209
Modeling in Therapy
149
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
149
Diagnostic and Statistical Manual of Mental Disorders (DSM)
151
The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
151


