一个多细胞自我组织的益生菌平台用于口服,增强了肠道殖民
Hua Liu1,2, Zhijie Chen3, Qiaowen Lin2
1Department of Geriatrics, Medical Center on Aging, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Nature communications
|August 1, 2025
概括
新的快速微殖民地服务 (EMS) 提供益生菌作为多细胞微殖民地. 与传统补充剂相比,这种创新系统显著提高了肠道殖民和治疗效果.
科学领域:
- 生物技术和生物工程 生物技术和生物工程
- 微生物学和肠道健康
背景情况:
- 稳定的肠道殖民对于益生菌的治疗效果至关重要.
- 传统的口服益生菌输送方法往往表现为肠道适应性差.
- 与浮游生物形式相比,多细胞细菌微殖民地对殖民具有优越的基因表达.
研究的目的:
- 设计和评估一种新的系统,用于有效的口服输送和增强益生菌的肠道殖民.
- 为了提高治疗结果,利用自我组织的益生菌微殖民地.
主要方法:
- 快速微殖民地服务 (EMS) 的开发,该系统将多细胞益生菌微殖民地封装在水凝微球中.
- 使用压力放松,抗酸的酸盐水凝用于可调节的营养供应和细胞外矩阵支持.
- 在小鼠体外和体内评估微殖民地生存能力,对肠道状况的耐药性和殖民率.
主要成果:
- 与浮游生物益生菌相比,EMS微殖民地对胃酸,胆盐和抗生素有较强的抵抗力.
- 在水凝中可变的空间约束调节了微殖民地生存能力和殖民潜力.
- 在体内研究显示,与常规益生菌相比,EMS的结肠殖民率高89倍,结肠殖民率高52倍.
结论:
- 该EMS系统提供了一种有效的策略,以自我组织的多细胞微殖民地形式提供益生菌.
- 这种方法显著改善了益生菌在肠道环境中的生存和殖民.
- 电子微生物系统 (EMS) 代表了先进益生菌疗法的临床可转化创新.
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