在HPV持久性,阴道微生物组和宫癌复发之间存在关联
Despina Tsementzi1,2, Rebecca Meador3, Tony Eng4
1Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA. dtsemen@emory.edu.
Journal of translational medicine
|August 1, 2025
概括
在幸存者中,持续的HPV感染和宫癌复发是常见的. 一个Prevotella-主导的阴道微生物组与更高的风险有关,这表明微生物组调节可以改善结果.
科学领域:
- 妇科瘤学 妇科瘤学
- 微生物组研究 微生物组研究
- 传染病流行病学 传染病流行病学
背景情况:
- 宫癌 (CxCa) 幸存者经常经历持续的人类乳头瘤病毒 (HPV) 感染和治疗后局部复发.
- 阴道微生物组 (VM) 可能会影响HPV动态和癌症结果.
- 了解VM,HPV和CxCa复发之间的相互作用对于改善幸存者护理至关重要.
研究的目的:
- 调查阴道微生物组动态与HPV持续性之间的关联.
- 探索VM组成和子宫癌复发 (CR) 在幸存者的关系.
- 确定微生物生物标志物,预测妇科癌症幸存者的治疗结果.
主要方法:
- 在49名接受IB-IIIC阶段CxCa辐射后疗法 (RT) 或化疗辐射治疗 (chemoRT) 的患者进行了长度研究.
- 在多个时间点 (治疗前和治疗后长达12个月) 进行阴道微生物组测序和HPV类型识别.
- 在治疗后4年内评估癌症复发情况.
主要成果:
- 33%的患者在2-3年内出现了CxCa复发.
- 阴道微生物组主要以Prevotella为主,乳球菌的流行率较低.
- 普雷沃特拉物种与CxCa复发和治疗后持续高风险HPV (hrHPV) 检测显著相关.
结论:
- 前伏特拉主导的阴道微生物组与持续的HPV和宫癌复发风险增加有关.
- 这些发现强调了微生物组在宫癌进展和治疗反应中的潜在作用.
- 微生物组调节策略,如益生菌,可能为改善CxCa幸存者的结果提供新的治疗方法.
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