在高血压患者中,自主功能障碍和动脉硬之间存在关联
Jijing Wang1, Chuanyu Gao2, Yiming Fan1
1Department of Cardiopulmonary Function, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, No.7 Weiwu Road, Jinshui District, Zhengzhou, 450003, Henan, China.
Scientific reports
|August 1, 2025
概括
较低的心率变化 (HRV),以正常至正常间隔 (SDNN) 的标准偏差表示,与高血压患者 (尤其是年轻患者) 的动脉硬度增加 (通过脚脉冲波速度测量) 有关.
科学领域:
- 心脏病学 心脏病学
- 自主神经系统功能 自主神经系统功能
- 血管健康 血管健康
背景情况:
- 心率变化 (HRV) 是自主神经系统 (ANS) 功能的一个关键指标.
- 动脉硬是心血管事件的重要危险因素.
- 高血压患者的HRV和动脉硬之间的关系需要进一步阐明.
研究的目的:
- 为了研究HRV之间的关联,特别是正常到正常间隔 (SDNN) 的标准偏差,和动脉硬性,通过手脚脉冲波速率 (baPWV) 测量.
- 在一组基本高血压患者中探索这种关系.
主要方法:
- 这是一项追溯性研究,涉及1132名基本高血压患者.
- 使用SDNN (HRV指标) 评估自主功能.
- 通过baPWV测量动脉硬度,通过SDNN三层分层的患者.
主要成果:
- 较低的SDNN三角形与年龄较大,高甘油三和高禁食血糖有关.
- 多变量回归证实了SDNN和baPWV (β=-3.60) 之间的独立负相关性.
- 后勤回归显示SDNN和升高的baPWV (OR=0.97) 之间存在负相关性,具有显著的非线性关联 (P<0.001).
- 在65岁以下的患者中观察到更强烈的关联 (相互作用P<0.05).
结论:
- 降低SDNN与高血压患者的动脉硬 (baPWV) 独立且负面相关.
- 这种关联在65岁以下的高血压患者中尤为明显.
- 研究结果表明,自主神经系统功能障碍与高血压中动脉硬之间存在联系.
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