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Updated: Sep 13, 2025

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice
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Published on: February 3, 2023

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在线粒体功能障碍时,2-基氨酸会调解棕色脂肪细胞的白化,并与核软化相结合

Harshita Kaul1,2, Lea Isermann1,2, Katharina Senft1,2

  • 1Institute for Mitochondrial Diseases in Ageing, Faculty of Medicine, University of Cologne, and University Hospital Cologne, Cologne, Germany.

Nature metabolism
|August 1, 2025
PubMed
概括

棕色脂肪组织 (BAT) 中的线粒体功能障碍会导致脂质滴滴的积累. 这是由代谢物D-2-基酸盐 (D-2HG) 驱动的,影响基因表达和核度.

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Mitochondria01:37

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The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
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