双表达 (原始肠细胞表现型和神经内分泌分化) 的胃腺癌:独特的高侵略性亚型
Bingzhi Wang1, Yinong Wang2, Na Cheng1,3
1Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Virchows Archiv : an international journal of pathology
|August 2, 2025
概括
双表达的胃腺癌 (DEGA) 显示出更糟糕的预后和转移的增加. 这种亚型表现出独特的分子特征,与神经内分泌癌不同,并影响治疗耐药性.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 胃腺癌 (GA) 是不同的.
- 一些GA亚型表现出双原始肠细胞 (PEP) 和神经内分泌分化 (NED).
- 这种双表达GA (DEGA) 的临床病理特征尚不清楚.
研究的目的:
- 调查DEGA的临床病理特征和预后.
- 为了比较DEGA与非双表达GA (nDEGA).
- 探索DEGA的分子特征和治疗影响.
主要方法:
- 186名胃腺癌患者的免疫组织化学.
- 蛋白质和mRNA表达的分析 (Synaptophysin,Chromogranin-A). 蛋白质和mRNA表达的分析.
- 在体外细胞系实验和单细胞RNA测序.
- 与公共数据集和神经内分泌癌 (NEC) 的比较.
主要成果:
- DEGA 患者 (41.4%) 的预后比 nDEGA (P=0.03) 更差.
- DEGA显示了较高的结节转移率 (50%与7.1%在T1,P=0.011) 与持续的NED特征.
- DEGA表现出明显的分子特征,茎状,以及对新辅助疗法的耐药性,与NEC不同.
结论:
- DEGA代表了胃腺癌的独特亚型,具有攻击性行为.
- DEGA与预后不佳,转移增加和治疗耐药性有关.
- 了解DEGA的独特特征对于有针对性的治疗策略至关重要.
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