血蛋白质组范围的关联研究表明,新型蛋白质与多种心血管疾病的发病有关
Jia-Hao Wang1, Shan-Shan Dong1, Wei Huang2
1Key Laboratory of Biomedical Information Engineering of Ministry of Education, Key Laboratory of Biology Multiomics and Diseases in Shaanxi Province Higher Education Institutions, Biomedical Informatics & Genomics Center, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, People's Republic of China.
Cardiovascular diabetology
|August 2, 2025
概括
这项研究使用全蛋白质组关联研究确定了72种与心血管疾病 (CVD) 风险有因果关系的蛋白质. 这些发现为CVD机制和潜在的治疗点提供了新的见解.
科学领域:
- 遗传学 是一个遗传学.
- 蛋白质组学是指蛋白质组学.
- 心血管医学 心血管医学
背景情况:
- 心血管疾病 (CVD) 是全球主要的死亡原因.
- 目前的心血管疾病治疗方法仅对有限数量的患者有效.
- 需要新的治疗目标来解决心血管疾病治疗的未满足需求.
研究的目的:
- 对26种心血管疾病进行第一个全蛋白质组关联研究 (PWAS).
- 为了确定用于心血管疾病治疗的新型蛋白质标.
- 利用来自英国生物银行制药蛋白质组学项目 (UKB-PPP) 的大型血蛋白质组学数据集.
主要方法:
- 使用UKB-PPP数据计算了SNP蛋白质重量.
- 综合权重与26种心血管疾病 (心脏,静脉,脑血管) 的GWAS总结统计.
- 采用PWAS的FUSION框架,并在独立的数据集中进行复制.
主要成果:
- 确定了155种与心血管疾病相关的蛋白质,其中72种通过孟德尔随机化显示因果关系.
- 发现了33种新型蛋白质,以前没有涉及心血管疾病GWAS,包括静脉血栓栓塞的PROC.
- 开发了18种疾病的诊断模型,其中14种实现AUC>0.8,表明具有强大的诊断潜力.
结论:
- 确定了72种对心血管疾病风险有因果影响的蛋白质.
- 提供了对心血管疾病病原体的新机制性见解.
- 突出了未来心血管疾病治疗的有希望的蛋白质标.
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