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探索脑成像衍生的表型与卵巢癌风险之间的因果关系:双向的门德尔随机化

Ting Liu¹, Xiaoqian Tuo², Huifang Zhao¹

¹Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, People's Republic of China.

Journal of ovarian research

|August 2, 2025

概括

这项研究使用脑成像数据,发现大脑结构和卵巢癌风险之间的因果关系. 某些特定的大脑区域,如前中心环和中轨道前皮质,可能表明未来的卵巢癌风险.

科学领域:

神经成像是一种神经成像.
在瘤学瘤学.
遗传学是一个遗传学.

背景情况:

卵巢癌可以改变大脑的结构和功能.
脑成像衍生的表型 (IDP) 可能提供有关卵巢癌风险的见解.

研究的目的:

使用孟德尔随机化 (MR) 调查大脑IDP和卵巢癌之间的因果关系.
探索IDPs作为卵巢癌风险评估的生物标志物的潜力.

主要方法:

利用了来自英国生物库结构和扩散MRI数据的587个大脑IDP.
采用了五种MR模型 (IVW,MR-Egger,加权中位数,加权模式,简单模式) 用单核酸多态 (SNP) 作为仪器变量.
进行了对结果验证的元分析.

主要成果:

确定了72个与卵巢癌风险相关的显著的IDP (65个在敏感性测试后是强大的).
揭示了一种双向关系:右前中心环皮层表面积增加与较高的卵巢癌风险相关 (OR=1.139).
发现与降低风险相关的右侧中枢轨道前皮层体积较大 (OR=0.839);反向MR显示与fornix/stria terminalis FA和 corona radiata OD相关.

结论:

确立了特定的大脑IDP和卵巢癌风险之间的因果关系.
建议IDP作为潜在的神经成像生物标志物用于卵巢癌风险分层.
强调需要对潜在的生物机制进行进一步研究.

关键词:

大脑成像衍生出来的表型因果关系是因果关系.门德尔的随机化进行元分析分析.卵巢癌是发生在卵巢中的癌症.

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