儿童结核病或肺炎是否会影响成年后的COPD或喘?
D Dey1, P Bhattacharyya2, D Roy3
1Department of Biotechnology and Dr. B.C. Guha Centre for Genetic Engineering and Biotechnology, University of Calcutta, Kolkata, India;, Department of Airway Diseases, Institute of Pulmocare and Research, Kolkata, India.
儿童结核病 (TB) 和肺炎与慢性阻塞性肺病 (COPD) 症状和肺功能恶化有关. 对喘的影响不那么显著,这表明儿童呼吸道感染是成年COPD的关键风险因素.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 呼吸系统健康 呼吸系统健康
背景情况:
- 儿童肺炎是已知的成人喘和COPD的前体.
- 这项研究调查了儿童结核病 (TB) 和成人呼吸道疾病之间的潜在联系.
研究的目的:
- 确定儿童结核病和肺炎是否与成年COPD和喘患者的临床和放射性表现有关.
- 评估儿童结核病和肺炎对成年人肺功能和呼吸系统症状的影响.
主要方法:
- 收集了来自4,345名呼吸系统患者的人口统计和临床数据,包括吸烟史和童年暴露.
- 对被诊断患有COPD和喘的患者进行了螺旋测量和胸部X射线.
- 分析了儿童结核病/肺炎和临床/放射学发现之间的关联.
主要成果:
- 患有儿童结核/肺炎的COPD患者的肺功能显著降低 (FEV1%,FVC%,FEF25-75%),慢性吐,感染和X射线异常增加.
- 单独在COPD患者中,儿童结核病与更严重的喘息,恶化和肺气相关.
- 患有童年肺炎的喘患者经历了反复感染和的吐.
结论:
- 儿童结核病和/或肺炎被确定为发展COPD的危险因素,结果较差.
- 这些儿童感染与COPD患者的症状恶化和螺旋计测量值降低有关.
- 儿童结核病/肺炎和喘之间的关联不那么明显.
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