探索身体活动和微量营养素对糖尿病病的影响:亚型特定的遗传相关性和门德尔随机化研究
Fang Li1, Linlin Dang2, Yanli Wang3
1College of Physical Education, Henan Normal University, Xinxiang, 453007, China. lifang200621@163.com.
Nutrition & metabolism
|August 2, 2025
概括
身体活动,特别是中度至强度的身体活动 (MVPA),显著降低了1型糖尿病的糖尿病病 (DN) 风险. 维生素E在降低2型糖尿病患者的DN风险方面也显示出前景.
科学领域:
- 遗传学和流行病学
- 代谢疾病 代谢疾病
- 营养科学 营养科学
背景情况:
- 糖尿病病 (DN) 是一个重大的健康挑战.
- 身体活动和微量营养素摄入量是对DN的潜在保护因素.
- 这些因素与DN之间的因果关系尚不清楚.
研究的目的:
- 研究身体活动和微量营养素摄入对糖尿病病风险的因果关系.
- 探索身体活动保护作用的潜在调解途径.
- 为了区分1型糖尿病 (T1DM) 和2型糖尿病 (T2DM) 的影响.
主要方法:
- 一项使用大规模全基因组关联研究 (GWAS) 数据的门德尔随机化 (MR) 研究.
- 作为暴露变量,中度至强烈的体力活动 (MVPA) 和休屏幕时间 (LST).
- 来自FinnGen联盟的数据用于T1DM和T2DM与DN;IVW和Wald比率估计作为初级分析.
主要成果:
- 基因预测的MVPA显著降低了与T1DM相关的DN风险 (OR=0.294),部分由体重指数 (BMI) 介导.
- 较高的维生素E (γ-托科菲罗尔) 水平显著降低了与T2DM相关的DN风险 (OR=0.261);α-托科菲罗尔也显示了保护性证据.
- 观察到MVPA和DN风险之间的负遗传相关性 (r=-0.143).
结论:
- 证实了身体活动对T1DM相关DN的保护作用,部分通过BMI.
- 突出了维生素E对T2DM相关DN的潜在治疗益处.
- 支持生活方式的修改和补充DN预防策略.
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