维生素D不足的早产婴儿的尿路和分泌:建立特定年龄的规范数据
Tomas Matejek1,2, Veronika Pokorna1,2, Vojtech Drahy3,4
1Department of Paediatrics, Charles University in Prague, Faculty of Medicine Hradec Kralove, Hradec Kralove, Czech Republic.
Acta paediatrica (Oslo, Norway : 1992)
|August 2, 2025
概括
非常低出生体重婴儿的尿路和分泌量因年龄和维生素D状况而异. 需要特定年龄的数据进行监测,以预防早产婴儿的骨病.
科学领域:
- 新生儿医学 新生儿医学
- 儿科脏病学 儿科脏病学
- 营养科学 营养科学
背景情况:
- 非常低出生体重 (VLBW) 的婴儿 (<1500g) 面临代谢性骨病的风险.
- 甲基丁治疗在VLBW婴儿中很常见,可能会影响矿物平衡.
- 了解和平衡对于VLBW婴儿护理至关重要.
研究的目的:
- 为了评估VLBW婴儿的尿 (Ca) 和 (P) 排泄,没有严重的发病率,用甲基丁治疗.
- 在这个人群中建立尿路Ca和P分泌的规范性数据.
- 研究维生素D状态对矿物质分泌和恒温的影响.
主要方法:
- 在81名VLBW婴儿的尿液Ca和P及其肌素比率的分析,每两周一次,直到第56天.
- 血清副甲状腺激素 (PTH),25-氧维生素D [25-(OH) D],总Ca,P和性酸酶 (ALP) 的评估.
- 在出院前进行骨密度计.
主要成果:
- 尿液中的Ca和P排泄与它们的肌素比率有显著差异.
- 维生素D状态影响了尿道矿物质分泌,可能是通过PTH调节,但不是血清矿物质或ALP.
- 规范性数据仅针对具有足够维生素D (>50nmol/L) 的婴儿建立.
结论:
- 提供了健康,维生素D充足的VLBW婴儿尿液Ca和P排泄的年龄特定的规范数据.
- 尿液中的矿物质分泌量随着产后年龄显著变化,需要个性化监测.
- 足够的维生素D对于和的恒温至关重要,影响从2个月起的Ca分泌和P水平.
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