低胆化酶是结肠直肠癌的潜在不良预后因素,具有瘤标志物负的瘤标志物
Tawfik Ali Hamood Alburiahi1,2, Lei Liang1,2, Weiqing Liu3
1Department of Surgical Oncology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Cancer reports (Hoboken, N.J.)
|August 2, 2025
概括
血清胆酶 (CHE) 是结直肠癌 (CRC) 患者的有害预后因素,其瘤标志物为阴性 (TMN). 乙基胆酶 (BCHE) 可能作为CRC预后和免疫治疗的生物标志物.
科学领域:
- 在瘤学瘤学.
- 生物化学 生化学
- 遗传学 是一个遗传学.
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因.
- 血清胆酶 (CHE) 是一种营养指标,也是CRC的潜在预测剂.
- 乙基胆酶 (BCHE) 是一种由肝脏合成的CHE酶.
研究的目的:
- 调查CHE水平和CRC患者的存活预后与阴性瘤标志物 (TMN) 之间的关联.
- 探索BCHE基因表达与CRC中的免疫细胞透之间的关系.
主要方法:
- 分析了1140名CRC患者的临床数据,包括瘤标志物和生化指标.
- 患者根据CHE水平和瘤标志物状态进行了分层分类,以进行生存分析.
- 在癌症和正常组织中分析了BCHE基因表达,并与临床因素相关联.
主要成果:
- 较低的CHE水平 (CHE低) 在TMN和瘤标志物阳性 (TMP) CRC组中显着与较差的整体存活率 (OS) 相关.
- 在TMN CRC中,CHE ≤5.4 U/L,BMI <18.5 kg/m2和pN2被确定为OS的独立有害预后因素.
- 在CRC组织中,BCHE的表达明显高于正常组织,并且与病理阶段,无进展生存率和免疫细胞透,特别是M2巨细胞具有积极的相关性.
结论:
- CHE是结直肠癌患者具有负瘤标志物的独立有害预后因素.
- BCHE可以作为一个有价值的生物标志物来预测CRC的预后,并对免疫治疗策略具有潜在的意义.
相关概念视频
01:27Peptic Ulcer
Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the mucus...
01:11Pyloric Obstruction
Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
01:20Cholecystitis
Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...