实施患者导航计划,以支持代表参与癌症临床试验
Sukh Makhnoon1,2, Fabian Robles1,3, Jessica L Lee1
1Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, Texas, USA.
Cancer medicine
|August 2, 2025
概括
一个患者导航程序成功地在临床试验中招募了各种瘤患者. 这一举措改善了获得金融导航的机会,并促进了未来试验的兴趣,解决了癌症研究入学方面的关键挑战.
科学领域:
- 在瘤学瘤学.
- 临床研究 临床研究
- 健康 公平 卫生 公平
背景情况:
- 临床试验招生面临多样性的挑战,影响研究结果的概括性.
- 在瘤学试验中,患者的代表性往往不足,特别是在少数群体中.
- 导航服务有可能改善临床试验中的患者意识,访问和保留.
研究的目的:
- 实施和评估一个患者导航计划,旨在提高癌症临床试验中的多元化招生和保留率.
- 评估患者导航计划在各种医疗保健环境中的可行性,可接受性和覆盖范围.
- 确定近似结果,如财务导航收据和表达的试验兴趣.
主要方法:
- 从2023年7月到2024年7月,在一所大学和一个安全网医疗保健系统中实施了一项患者导航计划.
- 覆盖范围,有效性,采用,实施和维护 (RE-AIM) 框架指导了评估.
- 数据收集包括程序记录,患者/工作人员调查和患者定性访谈.
主要成果:
- 该计划为429名瘤患者提供服务,与一般患者人群相比,西班牙裔/拉丁裔,女性和少数民族人群的代表性更高.
- 在未参加临床试验的接触患者中,47%表示未来有兴趣参加临床试验.
- 已经参加试验的92%的患者获得了维持治疗的财务导航支持.
结论:
- 患者导航是一种可行和可接受的方法,可以在癌症临床试验中接触到代表性不足的人群.
- 该计划在吸引优先人口和提供支持服务方面取得了成功.
- 需要进一步的研究来确认导航对临床试验招生和保留率的影响.
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