估计的脉冲波速度与非透析性CKD第3至第5阶段的冠状动脉斑块之间的关联:一个横截面研究
Li Wang1,2,3, Yiqin Shi1,2,3, Zhen Zhang1,2,3
1Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Journal of clinical hypertension (Greenwich, Conn.)
|August 2, 2025
概括
估计的脉冲波速度 (ePWV) 强烈预测慢性病 (CKD) 患者的带斑块. 管理动脉硬度对于晚期CKD的心血管健康至关重要.
科学领域:
- 心血管医学 心血管医学
- 腎臟病學 (nephrology) 是一種醫學.
- 血管生物学 血管生物学
背景情况:
- 在慢性病 (CKD) 患者中,心血管斑块很普遍,这表明心血管风险较高.
- 通过估计的脉冲波速度 (ePWV) 测量的动脉硬是血管健康的关键指标.
- 在CKD3-5期中,ePWV和动脉斑块之间的关系需要进一步阐明.
研究的目的:
- 调查ePWV与动脉斑块存在之间的关联,在患有CKD 3-5阶段的个体中.
- 探索糖尿病对这种关联的影响及其潜在的调解作用.
主要方法:
- 一项横截面研究包括199名患有CKD 3-5阶段的参与者.
- 用超声波评估了动脉斑块,并使用已确定的方程计算了ePWV.
- 使用后勤回归,子组和调解分析来检查关联和调解效应.
主要成果:
- 在对共变量进行调整后,发现了ePWV和动脉斑块 (OR:1.85;p < 0.001) 之间存在显著的关联.
- 与最低水平相比,最高的ePWV三位数显示 carotid 斑块的风险大大增加 (OR: 21.52; p < 0.001).
- 糖尿病被确定为影响ePWV-心状斑关系的重要因素,ePWV调解了糖尿病影响的32.9%.
结论:
- 在晚期CKD中,ePWV和动脉斑块之间存在强烈的关联.
- 根据ePWV的指标,动脉硬是CKD患者心血管风险分层的一个关键因素.
- 管理动脉硬可能对减轻心血管并发症很重要.
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