在基于人口的队列研究中,在患有慢性并发病的老年患者中,接种流感疫苗和中风的短期风险
Yuheng Wang1, Wenli Xu1, Chenyang Jin2
1Department of Chronic Non-Communicable Diseases and Injury, Shanghai Municipal Center for Disease Control & Prevention, Shanghai, China.
Journal of clinical hypertension (Greenwich, Conn.)
|August 2, 2025
概括
接种流感疫苗可显著降低中风风险54-73%的老年人有慢性疾病,如COPD,高血压或糖尿病. 这项研究强调了流感疫苗对弱势群体的保护性益处.
科学领域:
- 心血管健康 心血管健康
- 传染病流行病学 传染病流行病学
- 公共卫生 公共卫生
背景情况:
- 流感疫苗接种和中风风险之间的关联仍然不清楚.
- 患有慢性疾病 (COPD,高血压,糖尿病) 的老年人患中风的风险更高.
研究的目的:
- 评估流感疫苗接种对60岁以上的慢性肺炎和高血压或糖尿病患者中风1年风险的影响.
主要方法:
- 在中国上海进行的回顾性队列研究 (2017年8月至2019年7月).
- 利用了来自慢性疾病,心血管和免疫注册表的数据.
- 采用Cox比例危险回归,Poisson回归和倾向得分匹配进行分析.
主要成果:
- 流感疫苗接种与2017-2018 (aHR 0.27) 和2018-2019 (aHR 0.46) 季节的中风风险降低有关.
- 与未接种疫苗的个人相比,风险降低幅度在54%至73%之间.
- 敏感性分析证实了这种关联 (RR 0.26).
结论:
- 流感疫苗接种与慢性疾病的老年人中风的1年风险显著降低.
- 这些发现支持流感疫苗接种在高风险人群中预防中风方面的保护作用.
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