超分子水凝微针实现了三合一的抗菌伤口治疗
Yi Li1, Qian Deng1, Zhengtai Chen2
1Department of Plastic Surgery, The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, 310000, China.
Advanced healthcare materials
|August 2, 2025
概括
一种新的超分子水凝微针系统结合了光热疗法,硫化气体和菌体疗法,用于感染的伤口愈合. 这种创新方法显著加快了伤口的关闭,并减少了细菌负载.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 传染性疾病 传染性疾病
背景情况:
- 细菌感染阻碍伤口愈合,目前的治疗方法面临耐药性和有效性问题.
- 抗菌素耐药性和药物透能力低下限制了感染伤口的常规疗法.
研究的目的:
- 开发一个多功能微针系统,以改善受感染伤口的治疗.
- 将光热,硫化 (H2S) 气体和菌体疗法集成到一个单一的输送平台中.
主要方法:
- 使用素,凝,酸 (TA) 和FeS纳米粒子制造超分子水凝微针 (MN) 系统.
- 纳入T4菌体用于向性细菌感染治疗.
- 对NIR响应光热效应,H2S释放和抗氧化物质用于伤口愈合的评估.
主要成果:
- 该MN系统展示了NIR响应的光热效应和释放的H2S气体,清理反应性氧物种.
- 在体内研究显示,糖尿病感染小鼠模型的伤口关闭加速 (≈61.5%) 和减少炎症.
- 微针系统实现了针对伤口感染的95%的显著抗菌率.
结论:
- 开发的超分子水凝微针系统为感染伤口愈合提供了一个有前途的多功能策略.
- 光热,化学 (H2S) 和菌体疗法的整合提供了一种协同方法来对抗细菌感染并促进组织修复.
- 这个创新的平台解决了当前治疗方法的局限性,为先进的伤口护理解决方案铺平了道路.
相关概念视频
Hand hygiene
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
Combined Effects of Drugs: Synergism
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
Microbial Corrosion
Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
iChip
The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
Rapid Identification of Pathogens
MALDI-TOF MS has transformed clinical microbiology by offering a rapid and reliable method for pathogen identification. The traditional approach to microbial identification typically involves time-consuming culture techniques and biochemical tests, which can delay the initiation of appropriate antimicrobial therapy. MALDI-TOF MS avoids these delays by using characteristic ribosomal protein mass patterns of microbial cells, enabling accurate species-level identification within minutes.Principle...
Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...


