佐乐龙酸对牙周结构的年龄相关影响在正义牙负荷下
Ana Zilda Nazar Bergamo1, Francisco José Albuquerque de Paula2, Renato Corrêa Viana Casarin3
1Department of Pediatric Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo, Avenida do Café, s/n. Ribeirão Preto/SP 14040-904, Brazil.
European journal of orthodontics
|August 2, 2025
概括
在正义牙科治疗期间,龙酸 (ZOL) 对青少年和成年小鼠的膜骨和牙周组织产生不同的影响. 年龄影响 ZOL.
科学领域:
- 矯正牙科 矯正牙科是一種矯正牙科.
- 骨生物学 骨生物学 骨生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 佐勒龙酸 (ZOL) 是一种用于治疗骨疾病的双酸盐.
- 它对面骨和牙周组织的影响,特别是在正牙牙移动期间,尚未完全理解.
- 骨对ZOL的反应可能存在与年龄相关的差异.
研究的目的:
- 为了研究龙酸 (ZOL) 对膜骨,牙周带和骨的影响.
- 在青少年和成年小鼠的正牙力下评估这些效应.
- 检查ZOL早期和晚期半衰期对这些组织的影响.
主要方法:
- 青少年 (6周) 和成年 (12周) 的小鼠接受了一剂ZOL.
- 在ZOL给药后的1周和12周,应用了正牙力 (0.35N).
- 评估了气膜骨,牙周带,,骨质细胞活动和生化标志物.
主要成果:
- 在成人和青少年中,ZOL减少了牙位移和骨质细胞数量 (潜伏阶段).
- 牙周带厚度和血管数量在两个年龄组都下降,在成年人中更为如此.
- 在所有接受ZOL治疗的群体中,发现了水泥再吸收和气泡的不规则;晚期青少年的反应模仿了成年人的反应.
结论:
- 在小鼠的牙周带和膜骨中,zoledronic酸治疗引起了年龄相关的反应.
- 这项研究强调了ZOL在青少年和成年小鼠的正牙治疗期间对骨重塑的明显影响.
- 需要对骨重塑标记物的进一步研究,以阐明ZOL在不同阶段和年龄段的机制.
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