解读分子时钟:探索分子机制和对皮肤衰老的遗传影响
Horng Yih Ng1, Yuan Seng Wu2,3, Mohitosh Biswas4
1Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Biogerontology
|August 2, 2025
概括
遗传因素显著影响皮肤衰老. 本综述确定了关键基因和单核酸多态 (SNP) 与皮肤老化表型 (如纹和多色素) 相关,揭示了复杂的遗传相互作用.
科学领域:
- 皮肤病学和遗传学
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
背景情况:
- 皮肤衰老是一个复杂的生物过程,由内在的遗传倾向和外在的环境因素驱动.
- 了解皮肤衰老的遗传基础对于开发有针对性的干预措施至关重要.
- 现有研究已经确定了与各种皮肤衰老表型相关的众多遗传变异.
研究的目的:
- 系统地审查与人类皮肤衰老表型相关的遗传变异和分子机制.
- 识别皮肤衰老的遗传研究中的知识空白.
- 为未来皮肤遗传学研究方向提供见解.
主要方法:
- 在Scopus和Web of Science数据库上进行了系统的文献搜索.
- 纳入标准集中在Scopus或ISI Web of Science索引的人类遗传关联研究上.
- 使用Q-Genie工具评估研究质量,13项研究符合标准.
主要成果:
- 对99个基因中的115个单核酸多态 (SNP) 的分析揭示了与皮肤衰老的关联.
- OCA2基因经常与色素过高有关.
- 参与原体代谢,黑色素发生,氧化应激和皮肤机制的基因都与此有关;值得注意的SNP包括SPATA33 rs35063026和IRF4 rs12203592.
结论:
- 皮肤衰老的表型受到遗传因素的显著调节,包括影响细胞外基质完整性,黑色素发生和对环境压力因素的反应.
- 特定的遗传变异对皮肤衰老产生性作用,影响纹和色素.
- 在了解皮肤衰老的遗传结构方面仍然存在重大差距,需要进一步进行全面的遗传关联研究.
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