与代谢功能障碍相关的肝病的性别和性别差异
Rishitha Penmetsa1, Sasha Kapil1, Lisa B VanWagner2
1Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, 5959 Harry Hines Blvd, Suite HP4.420M, Dallas, TX, USA.
概括
性别和性别显著影响代谢功能障碍相关的脂肪性肝病 (MASLD) 和其进展. 了解这些差异对于开发MASLD有效的个性化治疗策略至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,是全球慢性肝病的主要原因.
- 在全球范围内,MASH和HCC等MASH和并发症的流行率和并发症正在增加.
- 性别和性别是MASLD流行病学和结果的关键因素,但尚未得到充分研究.
研究的目的:
- 审查生物性别和性别在MASLD/MASH患病率,疾病进展和临床结果中的多方面的作用.
- 分析MASLD发育和相关肝病理的年龄和性别特异趋势.
- 探索生活方式,激素因素和性别肯定激素治疗对MASLD的影响.
主要方法:
- 综合性文献综述研究研究的性别和性别差异在MASLD.
- 对不同年龄组和性别的MASLD患病率的流行病学数据的分析.
- 检查关于荷尔蒙和行为影响的临床前 (动物) 和临床数据.
主要成果:
- 男性的MASLD并发症比HCC更高,而女性的MASH肝硬化增加.
- 荷尔蒙差异 (雌激素,) 和与年龄相关的变化 (如绝经后) 显著调节肝硬化和炎症.
- 与性别相关的行为 (饮食,运动,酒精) 和性别肯定性激素治疗影响MASLD的进展和管理.
结论:
- 性别和性别是MASLD病理生理学的关键决定因素,影响疾病风险,进展和结果.
- 调整MASLD治疗策略以考虑性别和性别差异对于改善患者护理至关重要.
- 需要进一步的研究来阐明MASLD中性二态和性别的复杂相互作用.
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