血的无氧化指数和2型糖尿病中糖尿病病的风险:一个元分析
Danyan Min1, Junli Zhao1, Miao Liu1
1Department of Nephrology, Shanghai University of Medicine and Health Sciences affiliated Zhoupu Hospital, Shanghai, China.
Biomolecules & biomedicine
|August 2, 2025
概括
较高的血动脉生成指数 (AIP) 与2型糖尿病 (T2DM) 患者的糖尿病病 (DN) 有关. 这种关联在老年人中更强烈,突出显示AIP是关键风险指标.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
背景情况:
- 血动脉生成指数 (AIP) 是一种与心血管和风险相关的脂质生物标志物.
- 在2型糖尿病 (T2DM) 中,AIP和糖尿病病 (DN) 之间的特定关系需要进一步澄清.
研究的目的:
- 进行一项元分析,评估T2DM患者的AIP和DN之间的关联.
- 调查这种关联的潜在调节因素,如年龄.
主要方法:
- 在PubMed,Embase和Web of Science进行了系统的文献搜索.
- 包括来自10项观察性研究的11个数据集 (25,773名T2DM患者).
- 数据使用随机效应模型进行了合成,并进行了子组和元回归分析.
主要成果:
- 增加的AIP水平与增加的DN风险显著相关 (RR = 1.51,p < 0.001).
- 与年轻患者 (RR = 1.35) 相比,58岁及以上的患者 (RR = 1.66) 的相关性更为明显.
- 在各种研究设计,人口统计或DN定义中,没有发现关联的显著差异.
结论:
- 较高的AIP是T2DM患者DN的重要危险因素.
- 高龄增长放大了高AIP和DN之间的关联.
- AIP作为一个有价值的生物标志物用于预测T2DM个体的DN风险,特别是老年人.
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