一个与控制器板集成的多通道生物传感器,用于对心脏托洛-I的标准加法电压测量信号分析
Ali M Yehia1, Mahmoud A Tantawy2, Mohamed A Farag3
1Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, ET-11562, Egypt; Department of Chemistry, School of Life and Medical Sciences, University of Hertfordshire Hosted By Global Academic Foundation, New Capital, Garden City, Cairo, R5 New, Egypt.
一种新的多通道电化学免疫传感器可以加快心脏素I (cTnI) 在血清中的检测. 这种六个电极系统提供精确的背景校正和快速,可重复的结果,用于点的护理诊断.
科学领域:
- 电化学 电化学 电化学
- 生物传感器是一种生物传感器.
- 纳米材料是一种纳米材料.
背景情况:
- 传统的免疫传感器很慢,需要进行背景校正.
- 微型传感器通常面临速度和准确性的限制.
研究的目的:
- 开发一种快速而准确的多通道电化学免疫传感器,用于检测心脏素I (cTnI).
- 为了克服单电极免疫传感器的局限性.
主要方法:
- 一个多通道电化学免疫传感器与六个工作电极被制造使用多壁碳纳米管/碳酸盐功能化聚氨酸/黄金纳米粒子.
- 标准加法校准协议用于同时分析和背景校正.
- 差分脉冲电压测量用于信号测量.
主要成果:
- 免疫传感器实现了45分钟的快速检测时间.
- 观察到高可重现性 (RSD% = 2.64%),动态范围为0.05-0.5 ng/mL,检测极限为0.02 ng/mL.
- 人体血清样本的结果与化学发光免疫测试有很好的一致性.
结论:
- 多通道免疫传感器为cTnI检测提供了一种可行,廉价和可重复的方法.
- 这项技术显示出实际的诊断应用的潜力.
- 传感器的设计可实现高效的电子转移和抗体固定,以提高性能.
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