针对癌症中的高基因/MET轴:对天然化合物的治疗前景有希望
Pouya Goleij1, Mohammad Mahdi Heidari2, Hossein Motevalli3
1USERN Office, Kermanshah University of Medical Sciences, Kermanshah, 6715847141, Iran; PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
European journal of medicinal chemistry
|August 2, 2025
概括
自然化合物通过向肝细胞生长因子 (HGF) /MET通路,显示出对抗癌症的希望. 这些药物可以克服治疗耐药性,并提高各种癌症的治疗结果.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肝细胞生长因子 (HGF) /MET信号通路对于癌症的进展,转移和耐药性至关重要.
- HGF/MET信号的失调有助于瘤发生和多种癌症类型的不良预后.
研究的目的:
- 审查癌症中HGF/MET信号传递的分子机制.
- 探索针对HGF/MET轴的天然化合物的治疗潜力.
- 讨论正在进行的临床试验和MET向疗法的挑战.
主要方法:
- 文献综述综合了关于高风/MET途径和天然化合物的临床前和临床发现.
- 分子机制的分析,包括下游信号通路 (PI3K/AKT,MAPK/ERK,STAT3) 和上皮-介质酶过渡 (EMT).
- 评估天然化合物,如黄类药物,黄素,EGCG,红醇,甲福尔明和白醇对它们对HGF/MET的抑制作用.
主要成果:
- 自然化合物有效抑制HGF/MET信号传递,调节MET表达,并破坏下游通路.
- 植物化学物质向关键的瘤机制,如EMT和癌症干细胞维护,逆转化学抵抗.
- 特定的化合物,如阿皮基宁,奎尔丁,黄素,EGCG,和Honokiol显示强大的抗癌作用,一些与传统疗法协同作用.
结论:
- 天然化合物提供了一种有前途的治疗策略,可以对抗高基因/MET驱动的癌症,并有可能克服对当前疗法的耐药性.
- 植物化学物质可以作为辅助或替代剂来增强癌症治疗的疗效.
- 需要进一步的研究和临床试验,以充分利用天然化合物的瘤学潜力.
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