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来自Apostichopus japonicus的新型抗氧化和低血糖原蛋白:在制剂中,功能机制和结构-活性关系研究研究

Benyou Zhang¹, Likun Ren¹, Yilin Lu²

¹College of Food Science and Technology, Bohai University; National & Local Joint Engineering Research Center of Storage, Processing and Safety Control Technology for Fresh Agricultural and Aquatic Products, China Light Industry Key Laboratory of Marine Fish Processing, Jinzhou, Liaoning 121013, China.

|August 2, 2025

概括

海黄原蛋白产生了一种新型六,DCDPRL,具有强大的低血糖和抗氧化作用. 这种可以通过特定的受体相互作用来管理血糖和氧化应激.

科学领域:

海洋生物技术海洋生物技术
生物化学生物化学
药理学药理学是指药理学的学科.

背景情况:

海原蛋白富含疏水性氨基酸,对生物活性至关重要.
来自原蛋白的酸越来越多地被认为具有治疗潜力.

研究的目的:

为了识别和表征来自海黄瓜 (Apostichopus japonicus) 的新生物活性.
为了评估一个新发现的六的低血糖和抗氧化活性.

主要方法:

16个Apostichopus japonicus原蛋白序列的虚拟酶解产生片段.
分子对接和药理动力学分析以确定双功能六 (DCDPRL).
在体外激素清除试验 (DPPH,ABTS,OH,O2-) 和在斑马鱼幼虫中的体内研究.

主要成果:

鉴定了2647个活性片段;DCDPRL (717.788 Da) 显示出显著的低血糖和抗氧化特性.
在DCDPRL的研究中,DCDPRL在低IC50值的实验室中表现出强烈的基因清除.
在斑马鱼中,DCDPRL (250μM) 通过向GLP-1R,GIPR和Keap1.1来降低血糖和氧化损伤.

结论:

新型六类药物DCDPRL具有显著的双功能低血糖和抗氧化活性.
结构-活性关系分析强调了氨酸,氨酸,氨酸和酸对DCDPRL生物活性的重要性.

关键词:

抗氧化剂是一种抗氧化剂.亚波斯蒂科普斯 (Apostichopus japonicus) 是一个日本动物.生物活性酸是一种生物活性酸.低血糖是指低血糖的情况.分子对接是分子对接.结构活动关系结构活动关系斑马鱼的幼虫斑马鱼的幼虫

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