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Updated: Sep 13, 2025

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
06:10

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

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驱动T细胞发育和增强免疫力的可溶性Notch激活剂的设计

Rubul Mout1, Ran Jing1, Mayuri Tanaka-Yano2

  • 1Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.

Cell
|August 2, 2025
PubMed
概括

研究人员开发出新型可溶性蛋白质复合体, 激活细胞命运的关键调节器, 这些工程激动剂有效地促进T细胞分化和增强免疫反应,为免疫治疗和治疗开发提供了新的途径.

关键词:
口信号T细胞的发育T细胞免疫力计算式蛋白质设计来自iPSC的T细胞免疫疗法蛋白质激动剂可溶性 口激活疫苗的使用

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