在阿尔茨海默病进展和认知性中单细胞多区域表观基因组重组

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Updated: Sep 13, 2025

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
04:41

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

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Zunpeng Liu1, Shanshan Zhang1, Benjamin T James1

  • 1Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Cell
|August 2, 2025
PubMed
概括

这项研究揭示了阿尔茨海默病 (AD) 如何在单细胞分辨率下改变大脑表观基因组. 我们绘制了阿尔茨海默病的表观基因变化, 发现广泛的放松和侵蚀与认知衰退和性有关.

关键词:
阿尔茨海默病认知性表观基因侵蚀表观基因组信息表观基因稳定性表观遗传学疲的情况微质激活监管网络单细胞多组体

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