与癌症免疫疗法相关的免疫相关的不良事件
Smith Kungwankiattichai1, Amrita Desai2, Shelby Koppinger3
1Center for Hematologic Malignancies, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA; Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
癌症免疫疗法,包括细胞疗法,正在彻底改变治疗方法,但具有独特的毒性. 了解患者因素对于最大化癌症免疫治疗的益处和最小化癌症免疫治疗的风险至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症治疗方法 癌症治疗方法
背景情况:
- 免疫疗法,包括基于抗体和细胞疗法,是现代癌症治疗各种疾病状态的基石.
- 免疫疗法虽然非常有效,但具有独特的毒性,需要谨慎管理.
- 确定影响疗效和毒性因素对于优化患者治疗结果至关重要.
研究的目的:
- 审查瘤学中新兴的免疫效应细胞疗法.
- 强调患者选择对于最大化免疫疗法益处的重要性.
- 讨论与癌症免疫疗法相关的不良事件的风险因素.
主要方法:
- 随机对照试验和监管批准的文献审查.
- 对免疫疗法的疗效和毒性临床数据的分析.
- 探索影响治疗结果的患者相关因素.
主要成果:
- 免疫效应细胞疗法正在迅速扩大其适用范围.
- 与免疫疗法相关的显著毒性需要进行风险评估.
- 患者特异性因素显著影响免疫疗法疗效和风险效益平衡.
结论:
- 适当的患者选择对于成功的癌症免疫疗法至关重要.
- 对有效性和毒性预测生物标志物的进一步研究是有必要的.
- 为了平衡免疫治疗的好处和风险,需要对患者因素有全面的了解.
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