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METTL3通过在脊柱星球细胞中的A-依赖的JAK2/STAT3激活来调节骨癌疼痛

Ming Liu1, Lijun Yang1, Zhirong Yan1

  • 1College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China; Department of Anaesthesiology, Fujian Maternity and Child Health Hospital, Fuzhou, China.

Cellular signalling
|August 2, 2025
PubMed
概括

甲基转移酶类3 (METTL3) 通过在脊髓星球细胞中甲基化JAK2 mRNA来驱动骨癌疼痛. 抑制METTL3可降低神经炎症和疼痛,提供一种潜在的新疗法.

关键词:
天星细胞激活的激活骨癌的疼痛 骨癌的疼痛在METTL3中,METTL3是METTL3的第一个类型.鼠标模型模型神经炎症是一种神经炎症.

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