在Rezūm®中注射密度:少可能不等于多. 一个多中心的国际研究
I Schwartzmann1, S Secco2, A Farré1
1Servicio de Urología, Fundació Puigvert, Universidad Autónoma de Barcelona, Barcelona, Spain.
Actas urologicas espanolas
|August 2, 2025
概括
在良性前列腺阻塞的水蒸气热疗法 (WVTT) 中优化注射密度 (ID) 可能会提高治疗成功率. 较高的ID显示出对失败的保护作用,而不会增加并发症或影响性功能.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 最少侵入性的手术
背景情况:
- 水蒸气热疗法 (WVTT) 是一种针对良性前列腺阻塞的微创手术疗法 (MIST).
- 对于WVTT,最优的前列腺内注射次数还没有很好地定义.
- 本研究引入了注射密度 (ID) 作为评估WVTT结果的指标.
研究的目的:
- 评估注射密度 (ID) 对WVTT后治疗失败对良性前列腺阻塞的影响.
- 确定ID和术后并发症和性功能之间的关系.
主要方法:
- 在11个欧洲中心对722名接受WVTT的患者进行了多中心的回顾性研究.
- 收集的数据包括基线,手术和24个月后的术后结果.
- 逻辑回归分析了基于ID切断点 (0.75-2.5注射/10cc) 的治疗失败.
主要成果:
- 中间ID (1.25-1.75注射/10厘米) 显示出对治疗失败的保护作用,1.75达到统计学意义 (P=.028).
- 更高的ID (2.00-2.50注射/10cc) 也显示出保护作用,其中2.25达到显著性 (P=.024).
- 在ID和并发症之间没有发现显著的关联;性功能保持稳定.
结论:
- 在WVTT中优化注射密度 (ID) 可能会提高良性前列腺阻塞的治疗成功率.
- 根据ID指导的WVTT体积方法,与线性注射技术相比,可以提供更好的结果.
- 更高的ID可以安全地实施,而不会对并发症或性功能产生不良影响.
相关概念视频
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
631
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
631
Bioavailability Study Design: Single Versus Multiple Dose Studies
388
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
388
Bioavailability Study Design: Healthy Subjects Versus Patients
252
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
252
Dose Size and Dosing Frequency: Determination Methods
817
Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
817
Drug Accumulation During Multiple Dosing: Repetitive IV Injections
531
Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
531
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
428
Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
428


