酒精,吸烟,以及它们的协同作用,是发生2型糖尿病的危险因素
Indira Paz-Graniel1, Junko Kose2, Pauline Duquenne3
1Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Alimentació, Nutrició, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Nutritional Epidemiology Research Team (EREN), INSERM, INRAE, CNAM, Center of Research in Epidemiology and StatisticS (CRESS), Université Sorbonne Paris Nord and Université Paris Cité, Bobigny, France; CIBER de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain; Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain.
吸烟显著增加了2型糖尿病的风险,而酒精消费没有保护作用. 结合吸烟和大量饮酒并没有增加风险,因此需要进一步调查这些关系.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 吸烟是2型糖尿病的一个已知的危险因素.
- 关于酒精消费与2型糖尿病风险之间的关联仍在争论中.
- 吸烟和酒精对2型糖尿病风险的综合影响需要进一步研究.
研究的目的:
- 调查吸烟和饮酒对2型糖尿病风险的个人影响.
- 研究吸烟和酒精对2型糖尿病风险的综合影响.
- 分析来自大型队列的数据,以获得强大的统计能力.
主要方法:
- 分析了NutriNet-Santé队列 (2009-2023) 中110,076名参与者的数据.
- 使用多变量考克斯回归模型来评估关联.
- 评估吸烟和饮酒的个人和综合影响,包括重度使用类别.
主要成果:
- 过去和现在的吸烟与36%的2型糖尿病风险增加有关.
- 与轻度/中度吸烟相比,大量吸烟 (每天≥20支烟) 的风险增加了一倍以上.
- 饮酒,即使是大量饮酒,也与2型糖尿病风险没有显著联系.
结论:
- 吸烟被证实是2型糖尿病的独立危险因素.
- 酒精消费似乎没有提供对2型糖尿病的保护.
- 需要进一步的研究来了解酒精和烟草使用对2型糖尿病风险的联合影响和机制.
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