相关实验视频

Updated: Sep 13, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

新辅助化疗对口腔状细胞癌的临床结果和免疫微环境的影响

Zhu You¹, Tianqi Zhang², Mingyang Liu¹

¹Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China; Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan, 250021, China.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

|August 2, 2025

概括

对口腔状细胞癌 (OSCC) 的新辅助化疗 (NAC) 没有影响整体存活率,但改善了瘤下降阶段. NAC增加了CD8+PDL1+免疫细胞,表明OSCC治疗中联合化疗-免疫疗法的潜力.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症研究癌症研究

背景情况:

新辅助化疗 (NAC) 对口腔状细胞癌 (OSCC) 至关重要,但其免疫效应尚不清楚.
了解NAC对免疫检查点和瘤相关免疫细胞的影响对于优化OSCC治疗策略至关重要.

研究的目的:

评估NAC对OSCC免疫学概况的影响.
在OSCC患者的NAC治疗前后,对免疫检查点和瘤相关免疫细胞的变化进行表征.

主要方法:

在OSCC治疗中,NAC (16例) 与单独手术 (18例) 的比较分析.
多重体免疫光用于分析12名OSCC患者 (6名NAC,6名对照) 的瘤样本中的免疫标记 (POXPE3,CD4,CD8,CD68,PD-1,PD-L1,CTLA-4,CD66b,CD16,CD19,Caspase-3,GSDMD).

主要成果:

在NAC和对照组之间,整体存活率没有显著差异.
在8名患者中,NAC治疗导致CD8+PDL1+表达下降,CD8+PDL1+表达增加 (P<0.05).
在NAC治疗的OSCC中观察到PD1+,PD1+,CTLA4+,Caspase+,CD8+PD1+,CD8+PDL1+和CD68+PDL1+细胞的密度增加;CD68+,CD16+,CD19+,CD66b+和GSDMD+细胞的密度减少.

结论:

通过减少瘤阶段,并使更具侵略性的手术能够在没有明显危害的情况下提高OSCC的临床结果.
在NAC后增加的CD8+PDL1+细胞表明增强了免疫反应途径,支持进一步研究将化疗与OSCC的免疫疗法结合起来.

关键词:

在CD8+PDL1+细胞中.多重复合的免疫光.新辅助化学疗法新辅助化学疗法口腔状细胞癌的癌症.瘤的免疫微环境

更多相关视频

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Published on: April 20, 2018

相关概念视频

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...