一项前性研究,研究脂乙醇度与首次发生静脉血栓塞栓症的风险之间的关联
Magdalena Johansson1, Anders Själander2, Marcus M Lind1
1Skellefteå Research Unit, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
European journal of internal medicine
|August 2, 2025
概括
高度的酒精消费,以酸乙醇 (PEth) 来衡量,与静脉血栓塞栓症 (VTE) 的风险增加有关. 这种生物标志物可以识别出具有更高不良健康结果风险的个体.
科学领域:
- 心血管健康 心血管健康
- 临床生物标志物 临床生物标志物
- 与酒精有关的研究
背景情况:
- 已知饮酒对健康的负面影响,但由于依赖自我报告的数据,其与静脉血栓塞栓症 (VTE) 的联系仍然不清楚.
- 以前关于酒精消费和VTE风险的研究受到自我报告不准确性的限制.
- 这项研究解决了客观措施的需要,以了解酒精对VTE的影响.
研究的目的:
- 调查使用脂乙醇 (PEth) 客观测量的酒精消费与首次出现VTE的风险之间的关联.
- 使用一个经验证的生物标志物来更准确地评估酒精摄入量在VTE中的作用.
- 为了识别那些高酒精消费的个体,他们可能面临风险增加的VTE.
主要方法:
- 在瑞典北部进行了一项基于人口的嵌套病例参考研究.
- 来自Västerbotten干预计划 (VIP) 的数据包括1985-2014年的健康检查和血液样本.
- 用液体染色学双重质谱测量了酸乙醇 (PEth) 度,测量了1410例VTE病例和1410个匹配的参考人群.
主要成果:
- 在最高的PEth度类别 (>0.30μmol/L) 和增加静脉瘤风险 (OR 1.44;95% CI 1.05-1.98) 之间发现了显著的关联.
- 在对教育,BMI,吸烟,高血压和癌症进行调整后,这种关联仍然显著.
- 最低的PEth类别 (<0.01μmol/L) 作为参考组.
结论:
- 较高的PEth度独立地与患有首次VTE的风险更高有关.
- 氨酸乙醇 (PEth) 作为一种有价值的生物标志物,用于识别高酒精消费和高静脉瘤风险的个体.
- 这些发现强调了客观酒精生物标志物的重要性,以了解和减轻像VTE这样的不良健康结果.
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