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HMGA1对HNSCC瘤发生,预后和免疫微环境的影响:一项多omics研究

Ziang Xu^1,2, Moxu Wang^1,3, Jilin Cai^1,3

¹State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, China.

NPJ precision oncology

|August 2, 2025

概括

高流动性组AT-hook 1 (HMGA1) 在头部和部状细胞癌 (HNSCC) 中升高,促进瘤生长并表明预后不佳. cg25207224的口服冲洗测试可以预测HNSCC的结果.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
基因组学就是基因组学.

背景情况:

高流动性组AT-hook 1 (HMGA1) 与各种生物过程有关.
HMGA1在头部和部状细胞癌 (HNSCC) 中的特定作用仍然在很大程度上未被定义.

研究的目的:

综合调查HNSCC中HMGA1的功能和预后意义.
探索HMGA1与瘤遗传学的关系,免疫微环境,以及其作为非侵入性生物标志物的潜力.

主要方法:

整合来自公共和私人HNSCC队列的多主题数据.
分析HMGA1表达,体突变,瘤突变负担和免疫检查点相互作用.
单细胞RNA测序,体外和体外功能实验.
在口腔冲洗样本中分析cg25207224甲基化.

主要成果:

在HNSCC组织中,HMGA1的表达显著上调,与患者预后较差相关.
升高的HMGA1与明显的体质突变,增加的瘤突变负担和与免疫检查点的相互作用有关.
单细胞分析显示HMGA1在恶性HNSCC细胞中的丰富.
在体外和体外研究表明,HMGA1促进HNSCC细胞的增殖,迁移和激活.
cg25207224口腔冲洗样本中的甲基化显示出作为HNSCC的非侵入性预后标记物的潜力.

结论:

HMGA1显著影响HNSCC瘤发生,进展和瘤免疫微环境.
HMGA1代表了HNSCC的潜在治疗标.
cg25207224口腔冲洗样品中的甲基化为HNSCC预后提供了一个有前途的非侵入性生物标志物.

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