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Updated: Sep 13, 2025

Preparation of Primary Acute Lymphoblastic Leukemia Cells in Different Cell Cycle Phases by Centrifugal Elutriation
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Preparation of Primary Acute Lymphoblastic Leukemia Cells in Different Cell Cycle Phases by Centrifugal Elutriation

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扩大的PML核体触发了白血病细胞中冲突的细胞周期信号介导的细胞毒性

Tomohisa Baba1, Soichiro Kumamoto2, Yuta Moriguchi2

  • 1Division of Cancer and Senescence Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan. sergenti@staff.kanazawa-u.ac.jp.

Cell death & disease
|August 2, 2025
PubMed
概括

冲突的细胞循环信号,包括有菌性ERK信号和CDK4/6抑制,增强PML-核体的形成,诱导急性髓性白血病 (AML) 细胞的细胞毒性,并提高AML小鼠模型的治疗疗效.

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