在6-19岁的儿童中,尿中甲酸盐,酸盐和硫酸盐度与肺功能的相关性
Linlin Yu1, Shuang Shi2, Li Shen3
1Department of Traditional Chinese Medicine, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
BMC public health
|August 2, 2025
概括
儿童暴露于环境中的甲酸盐和酸盐与肺功能减弱有关,特别是在6至12岁的幼儿中. 氨酸暴露与肺功能没有显著的关联.
科学领域:
- 环境健康 环境健康
- 儿科肺病学 儿科肺病学
- 毒理学 毒理学 毒理学
背景情况:
- 人类广泛暴露于环境中的酸盐,酸盐和硫酸盐混合物是常见的.
- 这些环境化学物质对儿童肺功能的影响尚不清楚.
研究的目的:
- 为了研究尿中甲酸盐,酸盐和硫酸盐度与儿童和青少年肺功能之间的关联.
- 探索这些关联中的潜在年龄和性别差异.
主要方法:
- 来自美国NHANES (2007-2012) 的2,271名儿童和青少年 (6-19岁) 的数据分析.
- 通过尿路度的甲酸盐,酸盐和硫酸盐的暴露评估.
- 使用螺旋计进行肺功能评估.
- 使用线性回归和通用线性模型进行统计分析,并根据年龄和性别进行分层子组分析.
主要成果:
- 在一般人群中,甲酸盐和酸盐度与肺功能适度下降有关.
- 这些负面关联在较年轻的儿童 (6-12岁) 中更为明显.
- 在6-12岁的儿童中,甲酸盐与男孩的FEV1降低有关,酸盐与男女FEV1,FVC和PEF降低有关.
结论:
- 甲酸盐和酸盐暴露与儿童和青少年的肺功能受损有关.
- 对肺功能的不良影响在较小的儿童 (6-12岁) 中更为显著.
- 建议对大型潜在队列进行进一步研究,以证实这些发现.
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