血红蛋白糖化指数和中风死亡率的年龄相关变化:在队列研究中调解和机器学习
Xinyu Tong1, Jianxiong Gu1, Chuxin Lyu2
1Department of Neurology, Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 214000, China.
Scientific reports
|August 2, 2025
概括
较高的血红蛋白糖化指数 (HGI) 与缺血性中风 (IS) 患者的更好的生存率有关,可能会调解年龄和死亡风险之间的关系. 这一发现对于理解IS患者的结果至关重要.
科学领域:
- 临床医学 临床医学
- 心脏病学 心脏病学
- 老年学是一门学科.
背景情况:
- 缺血性中风 (IS) 对患者的生存构成重大威胁.
- 了解影响IS患者短期和长期死亡率的因素对于改善临床管理至关重要.
- 血红蛋白糖化指数 (HGI) 在IS死亡率中的作用,特别是其与年龄的相互作用,需要进一步调查.
研究的目的:
- 为了检查年龄,血红蛋白糖化指数 (HGI) 和IS患者30天和1年死亡率之间的关联.
- 分析HGI对IS患者年龄与死亡率之间的关系的潜在调解作用.
- 评估HGI对IS死亡风险的预测性能.
主要方法:
- 利用了MIMIC-IV数据库中的3269名IS患者的数据.
- 采用后勤,Cox和LASSO回归分析来评估年龄和HGI对死亡率的影响.
- 应用了非线性关系的限制立方线 (RCS) 分析,调解效应的调解分析,以及对生存差异的受限制平均存活时间 (RMST) 的卡普兰-梅尔 (K-M) 曲线.
主要成果:
- 较低的HGI和年龄较大与30天和1年死亡风险的增加显著相关 (P < 0.001).
- RCS分析表明HGI和死亡风险之间存在J形关系.
- 调解分析表明,HGI对年龄与死亡率的关系有负面调解作用,更高的HGI与更好的生存概率相关.
结论:
- 年龄和HGI是IS患者短期和长期死亡率的显著相关系数.
- 在IS中,HGI可能部分调解年龄对死亡风险的影响.
- 较高的HGI水平与IS患者的生存结果改善有关,突出显示其作为预后标记物的潜力.
更多相关视频
09:35A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
Published on: November 15, 2024
515
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
376
相关概念视频
Regression Toward the Mean
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when researchers try to extrapolate results...
Statistical Methods for Analyzing Epidemiological Data
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
Life Tables
A life table is a statistical tool that summarizes the mortality and survival patterns of a population, providing detailed insights into the likelihood of survival or death across different age intervals within a cohort. By organizing data on survival probabilities and mortality rates, life tables offer a clear snapshot of population dynamics over time. They are extensively used in demography, public health, actuarial science, and ecology to analyze life expectancy, design health interventions,...
Actuarial Approach
The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Applications of Life Tables
Life tables are versatile across various fields, providing a quantitative basis for analyzing mortality and survival rates. Whether used by demographers, actuaries, epidemiologists, or sociologists, life tables offer valuable insights into the dynamics of life and death, facilitating informed decisions in public health, insurance, conservation, and beyond. Their broad applicability highlights the interconnectedness of demographic data with practical outcomes in everyday life and strategic...
