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Updated: Sep 13, 2025

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

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由PKA驱动的SPP1激活是一种连接骨微环境与前列腺癌进展的新机制

Pablo Sanchis1,2,3,4, Agustina Sabater1,2,3,4, Julia Lechuga2,3

  • 1Department of Genitourinary Medical Oncology and The David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Oncogene
|August 2, 2025
PubMed
概括

骨微环境通过蛋白激酶A (PKA) 信号刺激前列腺癌 (PCa) 的进展,增加骨质素 (SPP1/OPN) 的表达. 这个PKA/SPP1轴对治疗耐药性至关重要,并识别需要向治疗的瘤.

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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer07:25

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