在转移性非状NSCLC中,肉病和PET成像指标的预测价值
İsmet Seven1, Mehmet Akif Karacan2, Semanur Özsan Çelebi1
1Ankara Bilkent City Hospital, Medical Oncology Clinic, Ankara, Turkey.
Biomarkers in medicine
|August 3, 2025
概括
麻症和18F-FDG PET/CT上的不良代谢指标与转移性非状非小细胞肺癌 (nsNSCLC) 患者的存活率下降有关,这表明预后不佳.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是指放射学
- 代谢成像 - 代谢成像
背景情况:
- 转移性非小细胞肺癌 (NSCLC) 的预后不佳,存活率低于10%.
- 麻症和代谢指标是癌症患者潜在的预后因素.
研究的目的:
- 调查18F-FDG PET/CT从转移性非状NSCLC (nsNSCLC) 中对缩症和代谢指标的预后影响.
主要方法:
- 分析了124名转移性nsNSCLC患者,在诊断时接受了18F-FDG PET/CT.
- 通过L3骨肌指数评估的肉类;对全身和原发性瘤测量代谢指标 (SUVmax,MTV,TLG).
- 总生存率 (OS) 和肉症率是主要终点.
主要成果:
- 在74.2%的患者中出现了sarcopenia,与非sarcopenic患者的9.8个月相比,与4.7个月的中位数OS相关.
- 多变量分析确定了sarcopenia,SUVmax_T,MTV_T,TLG_T和SUVmax_WB作为OS的独立预测因素.
- 不良的代谢指标和肉类与降低生存率相关.
结论:
- 麻症和18F-FDG PET/CT上的不良代谢指标与转移性NSCLC患者的生存结果较差有关.
- 这些发现凸显了成像衍生型肉症和代谢性瘤特征的预后价值.
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