[Sirtuins:冠状细胞衰老的分子细胞机制.]
V N Khabarov1, E S Mironova2,3,4, D Ngoc Hop5
1Scientific Research Center of Hyaluronic Acid, 38/16 Komsomolsky pr., Moscow 119146, Russian Federation.
Advances in gerontology = Uspekhi gerontologii
|August 3, 2025
概括
赛尔图因蛋白质通过调节炎症,细胞衰老和新陈代谢,在关节疾病如骨关节炎中发挥着至关重要的作用. 调节Sirtuin活性为关节健康提供了潜在的治疗策略.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 类风湿病学 类风湿病学
背景情况:
- 赛尔图因蛋白质越来越多地被认为与关节疾病的病原发生有关.
- 它们在炎症,细胞衰老和关节组织内的代谢调节中的作用正在积极研究中.
- 新兴的研究突出了sirtuins,昼夜节律和关节病理的发展之间的联系.
研究的目的:
- 在关节疾病的发展和进展的背景下,审查Sirtuin蛋白质的多方面的作用.
- 阐明sirtuins影响状细胞功能和软骨健康的机制.
- 探索针对关节病理治疗的向思因活性的治疗潜力.
主要方法:
- 关于sirtuins和关节疾病的实验和临床研究的文献综述.
- 对分子信号通路的分析,其中涉及红细胞中sirtuins.
- 检查sirtuin对细胞衰老,新陈代谢和软骨中的亡的影响.
主要成果:
- 赛尔图因在关节组织中表现出对代谢压力和细胞衰老的保护作用.
- 它们调节细胞代谢,亡和自,从而保持软骨的完整性.
- 赛尔图因积极影响状细胞的功能活动,促进软骨的合成,抵消与年龄相关的衰退.
结论:
- 赛尔图因蛋白质是关节疾病的关键调节剂,影响炎症,衰老和新陈代谢.
- 了解Sirtuin介导的信号通路对于开发用于骨关节炎和其他关节病理的新疗法至关重要.
- 准sirtuin活动为增强状细胞功能和促进软骨修复提供了一个有希望的途径.
相关概念视频
01:37Mitochondria
15.0K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
15.0K
01:19The Effect of Aging on Tissues
2.5K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.5K
01:26Aging
183
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
183
03:00Molecular Chaperones and Protein Folding
18.4K
The native conformation of a protein is formed by interactions between the side chains of its constituent amino acids. When the amino acids cannot form these interactions, the protein cannot fold by itself and needs chaperones. Notably, chaperones do not relay any additional information required for the folding of polypeptides; the native conformation of a protein is determined solely by its amino acid sequence. Chaperones catalyze protein folding without being a part of the folded protein.
The...
The...
18.4K
02:58Regulated Protein Degradation
7.6K
It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
7.6K
01:26Protein Modifications in the RER
5.6K
Modification of secretory and transmembrane proteins entering the rough ER begins in the ER lumen. These modifications aid in protein folding and stabilize the acquired tertiary structure. Protein modifications in the rough ER co-occur at different stages of protein folding.
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal...
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal...
5.6K