精神病患者静脉血栓栓塞的危险因素:一个病例对照研究
Takuto Ishida1, Megumi Shimada2, Masafumi Mizuno3
1Department of Internal Medicine, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Journal of psychiatric research
|August 3, 2025
概括
精神病医院住院患者面临更高的静脉血栓栓塞 (VTE) 风险. 延迟的白内障和身体的克制显著增加了这种人群的静脉瘤风险,与一般医疗患者不同.
科学领域:
- 精神病学是一个精神病学.
- 内部医学 内部医学
- 临床药理学 临床药理学
背景情况:
- 精神病医院住院患者表现出静脉血栓塞栓症 (VTE) 的风险较高.
- 现有的关于精神病医院住院患者VTE危险因素的研究主要集中在基线因素上,对医院内触发因素的数据有限.
- 这项研究解决了关于精神病医院住院患者VTE的医院风险因素信息的稀缺问题.
研究的目的:
- 确定在精神病医院住院患者中导致静脉瘤发病率的特定医院内风险因素.
- 为了区分精神病与普通医疗住院患者的VTE风险概况.
主要方法:
- 在东京大都会松沢医院进行了一项回顾性,单中心病例控制研究.
- 从电子病历中提取了在住院期间被诊断患有VTE的患者的数据 (病例) 和匹配的对照.
- 采用多重逻辑回归分析来评估医院内因素 (如,身体克制,隔离和精神药物使用) 对静脉瘤风险的影响.
主要成果:
- 总共有11,819名患者住院治疗,其中108名 (0.9%) 被诊断为VTE (肺栓塞或深静脉血栓).
- 延迟的白内障 (OR: 10.1) 和身体克制 (OR: 6.7) 与增加VTE风险显著相关.
- 抗凝剂的使用表明具有保护作用,降低了静脉瘤风险 (OR:0.3).
结论:
- 在精神病医院住院患者中发现的VTE在医院内的风险因素与在医院住院患者中观察到的风险因素有很大差异.
- 进一步调查至关重要,以确定适合的候选人,在精神卫生保健机构的抗凝血剂预防.
- 这些发现凸显了精神病医院需要量身定制的VTE预防策略.
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