Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Catalysis02:50

Catalysis

27.6K
The presence of a catalyst affects the rate of a chemical reaction. A catalyst is a substance that can increase the reaction rate without being consumed during the process. A basic comprehension of a catalysts’ role during chemical reactions can be understood from the concept of reaction mechanisms and energy diagrams.
27.6K
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

8.6K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
8.6K
Factors Influencing the Rate of Chemical Reactions01:22

Factors Influencing the Rate of Chemical Reactions

5.8K
A variety of factors influence the rate of chemical reactions. For a chemical reaction to happen, atoms must collide with enough energy to overcome the repulsion between their electrons. This energy is called activation energy. Factors influencing the rate of reaction either lower the activation energy or increase the likelihood of a successful collision.
Concentration and Pressure:
The more particles present within a given space, the more likely those particles are to bump into one another....
5.8K
Radical Reactivity: Overview01:11

Radical Reactivity: Overview

2.2K
Radicals, the highly reactive species, gain stability by undergoing three different reactions. The first reaction involves a radical-radical coupling, in which a radical combines with another radical, forming a spin‐paired molecule. The second reaction is between a radical and a spin‐paired molecule, generating a new radical and a new spin‐paired molecule. The third reaction is radical decomposition in a unimolecular reaction, forming a new radical and a spin‐paired...
2.2K
Dynamic Equilibrium02:20

Dynamic Equilibrium

53.3K
A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...
53.3K
Catalytically Perfect Enzymes01:07

Catalytically Perfect Enzymes

4.1K
The theory of catalytically perfect enzymes was first proposed by W.J. Albery and J. R. Knowles in 1976. These enzymes catalyze biochemical reactions at high-speed. Their catalytic efficiency values range from 108-109 M-1s-1. These enzymes are also called 'diffusion-controlled' as the only rate-limiting step in the catalysis is that of the substrate diffusion into the active site. Examples include triose phosphate isomerase, fumarase, and superoxide dismutase.
 
Most enzymes...
4.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

20 Years of the ISCB Student Council Symposium: shaping computational biology and future leaders.

Bioinformatics advances·2026
Same author

Probing the dark energy in the functional protein universe.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Predicting Protein Folding Dynamics Using Sequence Information.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

Impact of the COVID-19 pandemic on computational biology early career researchers: A global retrospective study.

PLoS computational biology·2025
Same author

When artificial intelligence meets protein research.

Open research Europe·2025
Same author

Inferring protein-folding mechanisms from natural sequence diversity.

Biophysical journal·2025
Same journal

Metabolic disruptions through a three-dimensional genomic lens.

Current opinion in structural biology·2026
Same journal

Collective variable design for biomolecular conformational dynamics.

Current opinion in structural biology·2026
Same journal

Polymer scaling in protein crowding: From dilute coils to semidilute meshes.

Current opinion in structural biology·2026
Same journal

Tuning the physicochemical properties of rationally designed protein-based biomolecular condensates.

Current opinion in structural biology·2026
Same journal

Editorial overview: Folding, binding and protein design.

Current opinion in structural biology·2026
Same journal

Macromolecular crowding reshapes the conformational landscapes of intrinsically disordered proteins: mechanisms, cellular contexts, and functional consequences.

Current opinion in structural biology·2026
查看所有相关文章

相关实验视频

Updated: Sep 13, 2025

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
09:42

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

9.1K

挫折感,动态和催化作用

R Gonzalo Parra1, Diego U Ferreiro2

  • 1Life Sciences Department, Barcelona Supercomputing Center, Barcelona, Spain.

Current opinion in structural biology
|August 3, 2025
PubMed
概括
此摘要是机器生成的。

细胞通过酶催化利用热波动来维持生命. 蛋白质中的局部丧指导功能运动和催化功率,由进化优化.

更多相关视频

Multiscale Sampling of a Heterogeneous Water/Metal Catalyst Interface using Density Functional Theory and Force-Field Molecular Dynamics
10:52

Multiscale Sampling of a Heterogeneous Water/Metal Catalyst Interface using Density Functional Theory and Force-Field Molecular Dynamics

Published on: April 12, 2019

12.9K
Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes
12:08

Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes

Published on: June 24, 2022

3.7K

相关实验视频

Last Updated: Sep 13, 2025

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
09:42

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

9.1K
Multiscale Sampling of a Heterogeneous Water/Metal Catalyst Interface using Density Functional Theory and Force-Field Molecular Dynamics
10:52

Multiscale Sampling of a Heterogeneous Water/Metal Catalyst Interface using Density Functional Theory and Force-Field Molecular Dynamics

Published on: April 12, 2019

12.9K
Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes
12:08

Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes

Published on: June 24, 2022

3.7K

科学领域:

  • 生物物理学的生物物理.
  • 生物化学 生物化学
  • 计算生物学 计算生物学

背景情况:

  • 细胞生命依赖于化学潜力的受控消散.
  • 酶催化使精确有效的生物转化成为可能.
  • 局部丧是连接蛋白质动态和催化功能的关键概念.

研究的目的:

  • 审查了解局部丧,蛋白质动力学和催化功率之间的关系的最新进展.
  • 探索当地的挫折如何塑造蛋白质能量景观和利用热波动.
  • 检查进化序列调在优化局部丧模式中的作用.

主要方法:

  • 蛋白质能量景观的理论分析.
  • 蛋白质动态的实验研究.
  • 对酶机制的计算研究.
  • 对蛋白质科学近期文献的综述.

主要成果:

  • 局部挫折会产生能量景观的度,指导蛋白质运动.
  • 这些度有效地利用热波动用于功能目的.
  • 进化序列的变化调节了局部丧,使其接近最佳水平.
  • 理论,实验和计算的融合支持了局部丧的作用.

结论:

  • 局部丧是控制酶催化和蛋白质功能的一个基本原则.
  • 该概念为了解蛋白质动态和催化效率提供了一个统一的框架.
  • 进化过程已经为最佳的生物性能微调了局部丧.