在慢性阻塞性肺病中,以三醇稳定的伊卡林微粒中的微粒准IL-4通路
Chengwei Jiang1, Satyanarayana Somavarapu1
1Department of Pharmaceutics, School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.
这项研究开发了一种可吸入的微粒中的微粒系统,用于输送伊卡林 (ICA) 用于治疗慢性阻塞性肺病 (COPD). 该配方有效地将ICA传递给巨细胞,减少了与COPD相关的炎症.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物运输 药物运输 药物运输
- 呼吸系统医学 呼吸系统医学
背景情况:
- 慢性阻塞性肺病 (COPD) 是一种进展性炎症性肺病,治疗选择有限,针对其根本原因.
- 伊卡里因 (ICA) 是一种天然的黄类化合物,具有有益于COPD的抗炎和抗氧化特性,但其溶解性不佳阻碍了临床使用.
- 需要有针对性的肺输送系统来克服ICA对COPD治疗的生物可用性限制.
研究的目的:
- 开发和描述一种新的干粉吸入系统,用于肺部输送伊卡林 (ICA).
- 评估ICA配方在调节COPD相关的巨细胞活动中的体外疗效.
- 评估该系统在针对性治疗和COPD治疗干预方面的潜力.
主要方法:
- 使用DSPE-PEG2000/DPPC和trehalose通过喷雾干燥用于ICA封装的微粒中的微粒的开发.
- 微粒子空气动力学特性 (MMAD,发射剂量,FPF) 对于呼吸能力的表征.
- 在实验室中评估巨细胞吸收ICA载菌及其对M2极化标记物的影响 (CD206,IL-4).
主要成果:
- 产生了可呼吸的微粒 (MMAD 2.36 ± 0.3μm),具有高排放剂量 (93%) 和FPF (44%).
- 配方表现出稳定性,ICA被封装在无形状态中,并且在再水后保留了状结构.
- 实验室研究表明,巨细胞增加了ICA的吸收,M2巨细胞极化显著减少 (73%).
结论:
- 开发的可吸入的微粒中的微粒系统为Icariin的肺输送提供了一个有前途的平台.
- 该配方有效地向巨细胞并抑制M2极化,这表明它有可能治疗COPD相关的炎症.
- 需要进一步的体内研究来确认COPD模型中的药理动力学,分布和治疗效应.
更多相关视频
06:29Adoptive Transfer of IL-33-Stimulated Macrophages into Bleomycin-Induced Mouse Models to Study Their Effect on Idiopathic Pulmonary Fibrosis In Vivo
Published on: May 5, 2023
07:32Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
相关概念视频
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Drugs that Stabilize Microtubules
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Chronic Obstructive Pulmonary Disease-V: Management
Smoking Cessation
