梯度水凝与生物活性玻璃用于肌骨接口再生:增强生物力学强度和同步组织再生
Ying Liu1, Junjie Xu2, Jieling Yuan1
1Shanghai Frontiers Science Center of Advanced Textiles, College of Textiles, Donghua University, Shanghai 201620, China; Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China.
Acta biomaterialia
|August 3, 2025
概括
这项研究开发了一种具有连续离子梯度的生物活性水凝,以模仿肌骨接口. 梯度水凝成功促进了多组织再生,并增强了肌插入修复的生物力学强度.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 组织工程是组织工程.
背景情况:
- 肌骨愈合是具有挑战性的,因为在接口的复杂,局部梯度结构.
- 破裂的肌插入具有有限的再生能力,在体育医学中构成重大问题.
研究的目的:
- 设计和制造一种具有连续离子度梯度的生物活性水凝,以模仿自然肌骨接口.
- 促进骨髓介质干细胞 (BMSCs) 转化为软骨细胞和骨质母细胞的分化,以增强肌骨再生.
主要方法:
- 使用生物活性玻璃 (BG),改性酸盐 (AlgMA) 和凝制造水凝,创建连续离子度梯度.
- 在体内实验中评估水凝在促进肌骨界面再生和评估细胞分化方面的有效性.
主要成果:
- BG梯度水凝显著增强了梯度矿化纤维软骨的形成 (35.65%),表现优于均水凝和对照组.
- 液凝促进了肌,纤维软骨和骨的同步再生,从而改善了肠道的生物力学强度.
- 通过离子梯度指导,证明了BMSCs成功分化为冠状细胞和骨质母细胞.
结论:
- 仿生BG梯度水凝支架有效支持修复肌插入突破损伤.
- 这种方法为功能硬软组织接口的再生提供了一个新的策略,适用于带骨和软骨软骨修复.
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