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Updated: Sep 13, 2025

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增加NMDAR活性和GluN2A-NMDAR沉默突触扩张,由慢性二胺治疗诱导

Caitlyn A Chapman1, Nadya Povysheva2, Jon W Johnson2

  • 1Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Neuropharmacology
|August 3, 2025
PubMed
概括

慢性二 (BZD) 使用通过修改NMDA受体 (NMDAR) 功能和表达而改变大脑激发/抑制平衡. 这项研究揭示了代谢如何影响突触中的NMDARs,这可能解释了耐受性和戒断.

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