[一种肠道代谢物加剧了压力引起的腹]
Narumi Ishihara1, Shunsuke Kimura1, Koji Hase1,2
1Faculty of Pharmacy, Keio University.
概括
刺激性肠综合征 (IBS) 是一种慢性肠道疾病,原因不明. 管理重点是通过饮食,减压和肠道健康来缓解症状,因为有效的治疗方法难以捉摸.
科学领域:
- 胃肠病学 胃肠病学
- 功能性胃肠道疾病 功能性胃肠道疾病
- 微生物组研究 微生物组研究
背景情况:
- 刺激性肠综合征 (IBS) 是一种常见的慢性功能性胃肠疾病.
- 诊断依赖于症状,排除了诸如炎症或癌症之类的有机疾病.
- IBS表现出各种症状,包括疼痛,腹,便秘和胀气,分为亚型.
研究的目的:
- 总结目前对IBS病因,风险因素和管理策略的理解.
- 突出IBS症状与SIBO,食物敏感性和精神疾病等疾病之间的联系.
- 强调压力,饮食和肠道微生物群在IBS病变发生中的作用.
主要方法:
- 审查有关IBS病理生理学,诊断和治疗的现有文献.
- 风险因素的分析,包括情绪压力,饮食成分 (FODMAP,质) 和肠道微生物群的改变.
- 检查诊断标准和治疗方法.
主要成果:
- IBS的病因在很大程度上是未知的,需要以症状为重点的治疗.
- 情绪压力是关键的危险因素,影响荷尔蒙和肠道运动.
- 饮食因素 (FODMAP,质) 和肠道失调,包括改变的微生物群组成和SCFA等代谢物,是显著的贡献者.
结论:
- 由于病理不明,目前没有有效的激进治疗IBS.
- 管理需要全面的方法,包括生活方式的改变,症状管理,心理支持和肠道环境监管.
- 针对SIBO等相关疾病或解决失生症可能会改善IBS症状.
相关概念视频
01:17Irritable Bowel Syndrome I: Introduction
388
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
388
01:17Drugs for Treatment of Diarrhea-Predominant IBS
294
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
294
01:20Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
318
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
318
01:18Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
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Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
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01:17Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents
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Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
327
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
420