在期婴儿中,贝他美沙潜伏期和新生儿低血糖症
Lauren A Buckley1, Briana Clifton2, Katelyn M Tessier3
1Department of Pediatrics, Division of Neonatology, University of Minnesota, Minneapolis, MN, USA.
概括
在预产期婴儿中,产前甲 (BMZ) 暴露不会增加新生儿低血糖的风险,无论分娩时间如何. 然而,低查率意味着未被诊断的低血糖症仍然可能发生在这些婴儿中.
科学领域:
- 新生儿医学 新生儿医学
- 产科 产科 产科 产科 产科
- 药理学 药理学是指药理学的学科.
背景情况:
- 产前贝他他 (BMZ) 用于成熟胎儿肺部,但可以增加早产婴儿新生儿低血糖的风险.
- 长期婴儿 (GA≥37周) BMZ延迟对低血糖的影响并未得到很好的描述.
- 没有额外的风险因素的预产婴儿不会定期接受低血糖检查,这可能导致未被诊断的病例.
研究的目的:
- 为了确定产前BMZ给药和分娩之间的潜伏期是否会影响到期婴儿新生儿低血糖的发病率.
主要方法:
- 对758名接受产前BMZ并在≥37周生产的母婴二合体进行了回顾性队列研究.
- 新生儿根据BMZ暴露情况进行分类:<14天 (最近) vs>14天 (远程) 在分娩前.
- 主要结局:早期新生儿低血糖症 (48小时内<40毫克/分升). 二次结局:严重的低血糖和右糖治疗.
主要成果:
- 与远程BMZ组相比,最近的BMZ组在出生时的 GA 中位数较低,出生体重较低.
- 对于BMZ的指示在各组之间有所不同 (先兆子和早产).
- 早期低血糖症,严重低血糖症的发生率和需要进行乳糖治疗的发生率在最近和远程BMZ组之间没有差异.
结论:
- 在预产婴儿中,较短的延迟到BMZ的使用与降血糖的发病率或治疗的增加无关.
- 观察到低低血糖查率,使得未经诊断的低血糖的风险在BMZ暴露的新生儿未知.
- 需要进行前性研究,以更好地了解低血糖风险,并为暴露于BMZ的新生儿的查实践提供信息.
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