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酒精饮料消费与大脑小血管疾病负担之间的关联

Ben-Bo Xiong¹, Zi-Jie Wang², Zhi-Ming Li²

¹Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, No. 678 Furong Road, Shushan District, Hefei, China; Department of Clinical Medicine, The Second Clinical Medical College, Anhui Medical University, Hefei, China.

The journal of prevention of Alzheimer's disease

|August 3, 2025

概括

更高的酒精消费,特别是葡萄酒和烈酒,增加了脑小血管疾病 (CSVD) 的负担. 低酒摄入量可能有保护作用,强调需要适度饮酒,以保持大脑健康.

科学领域:

神经成像是一种神经成像.
流行病学流行病学
血管神经学血管神经学

背景情况:

饮酒模式与大脑小血管疾病 (CSVD) 之间的联系尚未完全理解.
调查特定的饮酒习惯和饮料类型对于澄清这种关系至关重要.

研究的目的:

检查总酒精摄入量,饮酒频率,饮料类型和CSVD负担之间的关联.
分析来自英国大型生物库队列的横截面数据.

主要方法:

利用了来自27326名英国生物库参与者的MRI数据,专注于21130名目前的饮酒者.
使用正常化白质超强度体积 (WMHV) 评估的CSVD负担.
采用多变量线性回归,调整人口统计,生活方式和血管风险因素.

主要成果:

与非饮酒者相比,酒精消费者表现出更大的CSVD负担.
增加饮酒频率 (每周≥5次) 和大量摄入葡萄酒/烈酒与更高的CSVD负担相关.
低至中度的酒/酒摄入量 (<3份/周) 与CSVD负担相反相关,而较高的乙醇摄入量增加了风险.

结论:

更高的酒精频率和数量,特别是葡萄酒和烈酒,与CSVD负担的增加有关.
低酒/酒消费可能会对CSVD产生保护作用.
适度饮酒对于保持脑血管健康至关重要.

关键词:

酒精消费酒精消费酒精消费大脑小血管疾病大脑小血管疾病饮酒频率饮酒频率英国生物银行.白质的超强度是白质的超强度.

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