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相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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相关实验视频

Updated: Sep 13, 2025

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
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多omics整合分析确定INPP4B是T细胞特定的激活抑制剂.

Ting Peng1,2, Qing Fang1, Zihao Zhao1

  • 1School of Life Sciences, Peking University, Beijing, China.

Clinical and translational medicine
|August 4, 2025
PubMed
概括

伊诺西多-4-酸酶B (INPP4B) 抑制T细胞的激活,并保持静止状态. 在耗尽的T细胞中INPP4B的上调表明其在癌症免疫治疗中的潜力.

关键词:
在INPP4B中使用.激活T细胞的激活过程这是一个多主题的多omics.

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Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
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Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
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相关实验视频

Last Updated: Sep 13, 2025

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
08:20

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

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Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

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科学领域:

  • 免疫学 免疫学 免疫学
  • 分子生物学分子生物学
  • 细胞生物学 细胞生物学

背景情况:

  • 原始的T细胞需要严格调节从静止状态过渡到激活.
  • 不调节的T细胞激活可以导致自身免疫性疾病和免疫耐受性受损.
  • 维持T细胞静止的机制尚未完全理解.

研究的目的:

  • 研究INPP4B在T细胞激活和静止中的作用.
  • 探索INPP4B作为癌症免疫治疗中的治疗点的潜力.

主要方法:

  • 多学科整合分析多学科整合分析
  • 染色素相互作用分析
  • 对T细胞激活和效应器功能的功能研究.

主要成果:

  • 在T细胞中INPP4B的表达很高,抑制T细胞的激活.
  • INPP4B形成T细胞特异的染色质相互作用域,在激活时减少.
  • 在瘤微环境中的耗尽的T细胞中,INPP4B的表达被上调.

结论:

  • 最佳INPP4B水平对于T细胞功能至关重要.
  • INPP4B是增强T细胞介导抗瘤免疫力的潜在目标.