在主观认知衰退中表征嗅觉,焦虑和抑郁症
Olivier Fortier-Lebel1,2,3, Émilie Hudon1,2, Sarah Brosse2,4
1Department of Psychology, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.
Journal of Alzheimer's disease : JAD
|August 4, 2025
概括
与健康对照人群相比,主观认知衰退 (SCD) 患者的嗅觉功能较差,焦虑和抑郁程度较高. 嗅觉测试与神经精神病学措施相结合,可以提高认知能力下降的预测.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 嗅觉功能障碍和神经精神症状是阿尔茨海默病 (AD) 的关键.
- 在主观认知衰退 (SCD) 中早期发现AD病理非常重要.
- 在SCD中存在嗅觉功能障碍需要进一步调查.
研究的目的:
- 为了比较SCD和健康对照 (HC) 个体之间的嗅觉功能和神经精神症状.
- 确定嗅觉缺陷是否存在于认知衰退 (SCD) 的前期阶段.
主要方法:
- 有110名老年人 (59名SCD,51名HC) 参与.
- 使用Sniffin' Sticks电池评估的嗅觉功能.
- 通过验证的问卷进行测量焦虑和抑郁.
主要成果:
- SCD组的全球嗅觉得分明显较低 (d=0.41).
- 与HC相比,SCD组报告的抑郁症 (d=1.07) 和焦虑症 (d=0.64) 较高.
- 嗅觉表现与焦虑/抑郁症相结合改善了组分类.
结论:
- 在SCD患者中存在微妙的嗅觉障碍.
- 嗅觉和神经精神病学评估可能有助于早期识别认知能力下降.
- 需要使用电生理学方法进行进一步的研究,例如嗅觉唤起的潜能.
相关概念视频
Olfaction
45.2K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
45.2K
Negative and Cognitive Symptoms of Schizophrenia
125
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
125
Olfactory Receptors: Location and Structure
9.6K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.6K
Cognitive Development During Adulthood
279
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
279
Traits, Mood, and Subjective Wellbeing
131
Subjective well-being (SWB) refers to an individual's self-evaluation of their overall life satisfaction, happiness, and fulfillment. This multifaceted construct is typically assessed by analyzing the balance of positive and negative emotions alongside perceptions of life satisfaction. Personality traits such as neuroticism and extraversion are strongly associated with variations in SWB, offering critical insights into the underlying mechanisms of emotional well-being.
Neuroticism and...
Neuroticism and...
131
Factors Affecting Perception
1.8K
Perception is influenced by perceptual set, context, motivation, and emotion. Perceptual set, or perceptual expectancy, refers to the tendency to perceive things in a particular way, influenced by previous experiences and expectations. This phenomenon affects the interpretation of stimuli, creating a set of mental tendencies and assumptions that impact sensory perceptions of sound, taste, touch, and sight.
An illustrative example of a perceptual set is the scenario where an airline pilot told...
An illustrative example of a perceptual set is the scenario where an airline pilot told...
1.8K


