接种SARS-CoV-2疫苗对体外受精结果的影响
Adi Anis Heusler1,2, Amir Weintraub1,2, Diana Stein2
1The Adelson School of Medicine, Ariel University, Ariel, Israel.
Human vaccines & immunotherapeutics
|August 4, 2025
概括
mRNA COVID-19 疫苗接种没有影响体外受精 (IVF) 周期结果. 接受试管婴儿的接种疫苗的妇女的怀孕率与未接种疫苗的妇女相似,这表明疫苗对生育治疗的安全性.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 疫苗学 疫苗学 疫苗学
- 传染性疾病 传染性疾病
背景情况:
- 随着COVID-19大流行,疫苗的快速开发变得必要,mRNA疫苗获得了紧急使用授权.
- 对于那些寻求生育治疗和辅助生殖技术的个人进行COVID-19疫苗接种的安全性产生了担忧.
- 了解疫苗对体外受精 (IVF) 结果的影响对于患者咨询至关重要.
研究的目的:
- 评估最近的mRNA SARS-CoV-2疫苗接种对试管婴儿周期结果的影响.
- 为了比较接种疫苗和未接种疫苗的患者群体之间的怀孕率和其他试管婴儿指标.
主要方法:
- 一项回顾性病例控制研究包括40岁以下接受试管婴儿的女性.
- 研究小组在试管婴儿前7天至6个月内接种了两剂Pfizer-BioNTech mRNA疫苗.
- 对照组由同期和前几年的未接种疫苗的患者组成.
主要成果:
- 385名妇女符合入选标准 (36名接种疫苗,349名未接种疫苗).
- 群体之间的人口和临床特征是可比的.
- 怀孕率相似:疫苗接种组的33.3%,对照组的31.8% (p > 0.1).
- 在试管婴儿周期的结果中没有观察到统计学上显著的差异,在接种疫苗的患者中出现了较高率的非显著趋势 (OR 1.17).
结论:
- 最近的mRNA SARS-CoV-2疫苗接种似乎不会影响试管婴儿周期的结果.
- 接种COVID-19疫苗对接受试管婴儿的妇女的怀孕率没有产生负面影响.
- 这些发现支持mRNA疫苗接种对使用辅助生殖技术的患者的安全性.
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