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Updated: Sep 13, 2025

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C ((sp3) -H 氨基衍生铜的氨基化

Maxwell S Reese1, Joshua A Queener1, Curtis E Moore1

  • 1Department of Chemistry & Biochemistry, The Ohio State University, 100 W 18th Avenue, Columbus, Ohio 43210, United States.

Journal of the American Chemical Society
|August 4, 2025
PubMed
概括

研究人员用氨 (NH3) 和胺 (NH2) 连接物合成铜复合物. 它们在金属氨基复合物中实现了迄今为止最强的N-H键,使得C-H键转化为C-NH2键.

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Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
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Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
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